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M9480644.TXT
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1994-08-20
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Document 0644
DOCN M9480644
TI Continued drug use and other cofactors for progression to AIDS among
injecting drug users.
DT 9410
AU Ronald PJ; Robertson JR; Elton RA; Edinburgh Drug Addiction Study,
University of Edinburgh,; Scotland, UK.
SO AIDS. 1994 Mar;8(3):339-43. Unique Identifier : AIDSLINE MED/94304554
AB OBJECTIVE: To evaluate the effects of continued drug use and other
cofactors on progression to AIDS among HIV-infected injecting drug
users. DESIGN: A prospective study. SETTING: The Muirhouse Medical Group
in Edinburgh, Scotland, UK. SUBJECTS: A total of 156 HIV-infected
injecting drug users. MAIN OUTCOME MEASURES: Progression to AIDS and low
absolute CD4 counts. RESULTS: Of this group, 48% will have progressed to
AIDS 10 years after seroconversion. Age and low absolute T4 counts had a
significant effect on progression to AIDS, with older patients
progressing more rapidly. Sex had no significant effects on progression.
Absolute CD4+ counts and the CD4:CD8 ratio were significant predictors
of progression among the group. Concurrent heroin injecting increased
the risk of progression to AIDS. No significant effects were observed
for use of other drugs. CONCLUSIONS: Our findings suggest that continued
drug use may have an accelerating effect on progression to AIDS. Age
also had an accelerating effect on progression, but sex had no
significant effects. In general, the study group did not appear to
progress at a different rate from other similar groups of HIV-infected
individuals, despite the fact that this was a relatively young cohort.
These data were based on accurate estimates of seroconversion dates.
DE Acquired Immunodeficiency Syndrome/BLOOD/EPIDEMIOLOGY/*ETIOLOGY
Adolescence Adult Age Factors Cohort Studies CD4-CD8 Ratio Female
Human HIV Infections/BLOOD/*COMPLICATIONS Leukocyte Count Male
Proportional Hazards Models Prospective Studies Risk Factors
Scotland/EPIDEMIOLOGY Substance Abuse, Intravenous/*COMPLICATIONS
Support, Non-U.S. Gov't Time Factors T4 Lymphocytes JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).